CLAM-2030 - Aplicaciones : Shimadzu Latin America

Paper

Masuda J. and Kato Y.:

Simultaneous Determination of Raltegravir, Dolutegravir, Elvitegravir, and Bictegravir in Human Plasma Using High-performance Liquid Chromatography-tandem Mass Spectrometry, Showa Univ J Med Sci. 32 (1), 91-102, 2020.

http://dx.doi.org/10.15369/sujms.32.91

Robin T., Saint-Marcoux F., Toinon D., Tafzi N., Marquet P., El Balkhi S.:

Automatic quantification of uracil and dihydrouracil in plasma, J Chromatogr B: 1142, 2020.

http://dx.doi.org/10.1016/j.jchromb.2020.122038

Robin T.,Barnes A.,Dulaurent S.,Loftus N.,Baumgarten S.,Moreau S.,Marquet P.,El Balkhi S.,Saint-Marcoux F.:

Fully Automated Sample Preparation Procedure to Measure Drugs of Abuse in Plasma by Liquid Chromatography Tandem Mass Spectrometry, Anal Bioanal Chem., 410: 5071-5083, 2018.

http://dx.doi.org/10.1007/s00216-018-1159-7

Nishiumi S, Shima K, Azuma T, Yoshida M.:

Evaluation of a novel system for analyzing hydrophilic blood metabolites, J Biosci Bioeng, 123:754-759, 2017.

http://dx.doi.org/10.1016/j.jbiosc.2017.01.015

Shimadzu Review

Shimadzu Review 74 [1・2] 11~17 (2017.9)	Analysis of 25-OH Vitamin D2/D3 and Steroids in Serum by a Fully Automated Sample Preparation LC/MS/MS System In the analysis of biological samples like serum by LC/MS/MS, sample preparation is required to carry out protein precipitation and sample dilution. These procedures risk causing variations and mistakes, depending on the operator’s procedure and experience. In this article, the validation of 25-OH vitamin D2/D3 and steroids in serum using a fully automated sample preparation LC/MS/MS system is described.

Analysis of 25-OH Vitamin D2/D3 and Steroids in Serum by a Fully Automated Sample Preparation LC/MS/MS System
In the analysis of biological samples like serum by LC/MS/MS, sample preparation is required to carry out protein precipitation and sample dilution. These procedures risk causing variations and mistakes, depending on the operator’s procedure and experience. In this article, the validation of 25-OH vitamin D2/D3 and steroids in serum using a fully automated sample preparation LC/MS/MS system is described.

Download Shimadzu Review

CLAM Applications

The following are examples of applications using a CLAM module.

Application	Target Compounds	Remarks
Antiepileptic drugs	Levetiracetam, Felbamate, Topiramate,Carbamazepine10-11-epoxide, Carbamazepine(CBZ), Tiagabine, Diazepam, Gabapentin, Pregabalin, PEMA, Lacosamide, Primidone, CBZ-Diol, Lamotrigine, 10-OH-CBZ, Rufinamide, Oxacarbazepine, Phenytoin, Perampanel, Retigabine, Stiripentol, Ethosuximide, Sultiame, Valpronic acid, Zonisamide, Phenobarbital, NDMS	Application News NO.C123
Antiarrhythmic drugs	Amiodarone, n-Desethylamiodarone, Sotalol, Bepridil, Flecainide, Pilsicainide, Cibenzoline, Mexiletine	Application News NO.C153
Immunosuppressant	Cyclosporin A, Tacrolimus (FK 506), Rapamycin (Sirolimus), Everolimus, Mycophenoloc acid(MPA), Mycopenolic acid glucuronide(MPA-G)	Maki Takane et al: transplantation, 65 (1) (2021) Technical Report (C297-0526)
Antibacterial drugs	Ciprofloxacin, Levofloxacin, Linezolid, Vancomycin, Gentamicin, Streptomycin, Amikacin, Teicoplanin, Daptomycin, Kanamycin, Neomycin B,Paromycin, Hygromycin C, Arbekacin
Antifungal drug	Voriconazole
Anticoagulant drugs	DOACs (Apixaban, Rivaroxaban, Edoxaban, Dabigatran), Acenocoumarol,Betrixaban,Fluindione, Warfarin	Daisuke Kawakami: Precision Medicine, 1(2) (2018) PO-CON1602E
Anticancer drug	5-FU（uracil and dihydrouracil）	Robin T., et al.: J Chromatogr B, 1142 (2020)
Steroids	Aldosterone, Cortisol, DHEA-S,Corticosterone, 17-OH-Progesterone, Progesterone, DHEA, Teststerone,Androstenedion,11-Deoxycortisol	PO-CON1691E Shimadzu Review, 74(1･2): 11~17 (2017)
Vitamin D	25-hydroxyvitamin D2, 25-hydroxyvitamin D3	PO-CON1692E PO-CON1826E Shimadzu Review, 74(1･2): 11~17 (2017)
Vitamin B1, B6	Thiamin Pyrophosphate(TPP), Pyridoxal-5’-Phoshate(PLP)
Vitamin A	Vitamin A
Metanephrin	Metanephrin, normetanephrine
Anti-viral drug	HIV：Integrase inhibitor（DTG、EVG、RAL、BIC） COVID-19 :Remdesivir and GS-441524, Favipiravir 　　　　Dexamethasone and antibiotics(Tazobactam, Meropenem,Piperacillin)	Shimadzu Review, 77(1･2) (2020) Application News NO. C217, C230, and other
Metabolomics	Primary metabolites	Nishiumi S et al., J Biosci Bioeng., 123(6) (2017) Application News No. C150
Anti-psychotic drugs	Aripiprazole, Clopazine, Dehydroaripiprazole, Desmethylclopazine, Haloperidol, N-Desmethylolanzapine, Norquetiapine, Olanzapine, Quetiapine, Risperidone, 9-OH-Risperidone, Amisulpride, Levomepromazine, Melperone, Perazine, Pipamperone, Promethazine, Sertindole, Sulpiride, Thioridazine, (Z)-Chorprothixene, Ziprasidone, Zotepine, Zuclopenthixol	IATDMCT_poster Neuroleptics
Drug of abuse(DOA)	2-Cl, 2C-B, 3,4-Methylenedioxypyrovalerone, 4-MTA, 6-acetylmorphine, 6-MAM,Amphetamine, Anhydroecgonine methyl ester, BDB, Benzoylecgonine, Buprenorphine, Cocaethylene, Cocaine, Codeine, Dextromethorphan, Dihydrocodeine, Ecgonine methylester, EDDP, Ethylmorphine, Hydrocodone, Hydoromorphone, Ketamine, MBDB, m-CPP, MDA, MDEA, MDMA, Mephedrone, Methadone, Methamphetamine, Methaqualone, Methcathinone, Methiopropamine, Methylphenidate, Morphine, Naloxone, Naltrexone, Nimetazepam, Norbuprenorphine, Norephedrine, Norfenfluramine, Norketamine Noroxycodone, Norpseudoephedrine, Oxycodone, Phencyclidine, Pholcodine, Propoxyphene, Ritalinic acid	Robin T., et al.:Anal Bioanal Chem., 410(20):5071-5083 (2018)
Medicinal toxicant	8 Barbiturate drug and Bromovalerylurea, 12 Tri-/Tetra-cyclic antidessant, 39 Benzodiazepines and their metamolites

For Research Use Only. Not for use in diagnostic procedures.