CLAM-2030 - Aplicaciones

Fully Automated Sample Preparation Module for LCMS

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Paper

Masuda J. and Kato Y.:

Simultaneous Determination of Raltegravir, Dolutegravir, Elvitegravir, and Bictegravir in Human Plasma Using High-performance Liquid Chromatography-tandem Mass Spectrometry, Showa Univ J Med Sci. 32 (1), 91-102, 2020.

http://dx.doi.org/10.15369/sujms.32.91

Robin T., Saint-Marcoux F., Toinon D., Tafzi N., Marquet P., El Balkhi S.:

Automatic quantification of uracil and dihydrouracil in plasma, J Chromatogr B: 1142, 2020.

http://dx.doi.org/10.1016/j.jchromb.2020.122038

Robin T.,Barnes A.,Dulaurent S.,Loftus N.,Baumgarten S.,Moreau S.,Marquet P.,El Balkhi S.,Saint-Marcoux F.:

Fully Automated Sample Preparation Procedure to Measure Drugs of Abuse in Plasma by Liquid Chromatography Tandem Mass Spectrometry, Anal Bioanal Chem., 410: 5071-5083, 2018.

http://dx.doi.org/10.1007/s00216-018-1159-7

Nishiumi S, Shima K, Azuma T, Yoshida M.:

Evaluation of a novel system for analyzing hydrophilic blood metabolites, J Biosci Bioeng, 123:754-759, 2017.

http://dx.doi.org/10.1016/j.jbiosc.2017.01.015

Shimadzu Review

Shimadzu Review 74 [1・2]
11~17 (2017.9)		 Analysis of 25-OH Vitamin D2/D3 and Steroids in Serum by a Fully Automated Sample Preparation LC/MS/MS System
In the analysis of biological samples like serum by LC/MS/MS, sample preparation is required to carry out protein precipitation and sample dilution. These procedures risk causing variations and mistakes, depending on the operator’s procedure and experience. In this article, the validation of 25-OH vitamin D2/D3 and steroids in serum using a fully automated sample preparation LC/MS/MS system is described.
Download Shimadzu Review

 

CLAM Applications

The following are examples of applications using a CLAM module.

Application Target Compounds Remarks
Antiepileptic drugs Levetiracetam, Felbamate, Topiramate,Carbamazepine10-11-epoxide, Carbamazepine(CBZ), Tiagabine, Diazepam, Gabapentin, Pregabalin, PEMA, Lacosamide, Primidone, CBZ-Diol, Lamotrigine, 10-OH-CBZ, Rufinamide, Oxacarbazepine, Phenytoin, Perampanel, Retigabine, Stiripentol, Ethosuximide, Sultiame, Valpronic acid, Zonisamide, Phenobarbital, NDMS Application News NO.C123
Antiarrhythmic drugs Amiodarone, n-Desethylamiodarone, Sotalol, Bepridil, Flecainide, Pilsicainide, Cibenzoline, Mexiletine Application News NO.C153
Immunosuppressant Cyclosporin A, Tacrolimus (FK 506), Rapamycin (Sirolimus), Everolimus, Mycophenoloc acid(MPA), Mycopenolic acid glucuronide(MPA-G) Maki Takane et al: transplantation, 65 (1) (2021)
Technical Report (C297-0526)
Antibacterial drugs Ciprofloxacin, Levofloxacin, Linezolid, Vancomycin, Gentamicin, Streptomycin, Amikacin, Teicoplanin, Daptomycin, Kanamycin, Neomycin B,Paromycin, Hygromycin C, Arbekacin  
Antifungal drug  Voriconazole  
Anticoagulant drugs DOACs (Apixaban, Rivaroxaban, Edoxaban, Dabigatran), Acenocoumarol,Betrixaban,Fluindione, Warfarin Daisuke Kawakami: Precision Medicine, 1(2) (2018)
PO-CON1602E
Anticancer drug 5-FU（uracil and dihydrouracil） Robin T., et al.: J Chromatogr B, 1142 (2020)
Steroids Aldosterone, Cortisol, DHEA-S,Corticosterone, 17-OH-Progesterone, Progesterone, DHEA, Teststerone,Androstenedion,11-Deoxycortisol PO-CON1691E
Shimadzu Review, 74(1･2): 11~17 (2017)
Vitamin D 25-hydroxyvitamin D2, 25-hydroxyvitamin D3 PO-CON1692E
PO-CON1826E
Shimadzu Review, 74(1･2): 11~17 (2017)
Vitamin B1, B6 Thiamin Pyrophosphate(TPP), Pyridoxal-5’-Phoshate(PLP)  
Vitamin A Vitamin A  
Metanephrin Metanephrin, normetanephrine  
Anti-viral drug HIV：Integrase inhibitor（DTG、EVG、RAL、BIC）
COVID-19 :Remdesivir and GS-441524, Favipiravir
　　　    　Dexamethasone and antibiotics(Tazobactam, Meropenem,Piperacillin)
 		 Shimadzu Review, 77(1･2) (2020)
Application News NO. C217, C230, and other
Metabolomics Primary metabolites Nishiumi S et al., J Biosci Bioeng., 123(6) (2017)
Application News No. C150
Anti-psychotic drugs Aripiprazole, Clopazine, Dehydroaripiprazole, Desmethylclopazine, Haloperidol, N-Desmethylolanzapine, Norquetiapine, Olanzapine, Quetiapine, Risperidone, 9-OH-Risperidone, Amisulpride,  Levomepromazine, Melperone, Perazine, Pipamperone, Promethazine, Sertindole, Sulpiride, Thioridazine, (Z)-Chorprothixene, Ziprasidone, Zotepine, Zuclopenthixol IATDMCT_poster
Neuroleptics
Drug of abuse(DOA) 2-Cl, 2C-B, 3,4-Methylenedioxypyrovalerone, 4-MTA, 6-acetylmorphine, 6-MAM,Amphetamine, Anhydroecgonine methyl ester, BDB, Benzoylecgonine, Buprenorphine, Cocaethylene, Cocaine, Codeine, Dextromethorphan, Dihydrocodeine, Ecgonine methylester, EDDP, Ethylmorphine, Hydrocodone, Hydoromorphone, Ketamine, MBDB, m-CPP, MDA, MDEA, MDMA, Mephedrone, Methadone, Methamphetamine, Methaqualone, Methcathinone, Methiopropamine, Methylphenidate, Morphine, Naloxone, Naltrexone, Nimetazepam, Norbuprenorphine, Norephedrine, Norfenfluramine, Norketamine Noroxycodone, Norpseudoephedrine, Oxycodone, Phencyclidine, Pholcodine, Propoxyphene, Ritalinic acid Robin T., et al.:Anal Bioanal Chem., 410(20):5071-5083 (2018)
Medicinal toxicant 8 Barbiturate drug and Bromovalerylurea, 12 Tri-/Tetra-cyclic antidessant, 39 Benzodiazepines and their metamolites  

For Research Use Only. Not for use in diagnostic procedures.