Vol.5, Issue1-October 2017 CONTENT

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Featuring Clinical Research

Shimadzu Journal
Vol.5, Issue1-October 2017 (2,210 KB)

Clinical Research

	[Insight from Customer] Professor Daniel W. Chan from the Johns Hopkins University School of Medicine (Page 4-5) We interviewed Professor Daniel W. Chan from the Johns Hopkins University School of Medicine. His research is focused on the development and application of proteomic and immunologic techniques in the diagnosis, management, and understanding of cancer. The relationship with Shimadzu started in 2009 when the Johns Hopkins Center for Biomarker Discovery and Translation began utilizing Shimadzu's mass spectrometers (AXIMA QIT and Resonance), primarily for discovery and analysis of cancer-related glycoforms.
	[Glycan Analysis] Analysis of Glycan Structures Using Chemical Labeling and MALDI MSn Mass Spectrometry (Page 6-8) Glycans play important roles in the function of glycoproteins in the human body. In this study, an AXIMA ResonanceTM was used to generate MALDI-IT-TOF MSn spectra for the analysis of glycan sequences without multistep separation or enzymatic treatment. Combining the carbohydrate oxidation reaction and MSn analysis allowed monitoring the oxidization reaction for sialylation and linkages of oligosaccharides.
	[Neuroscience] The Grand Challenge to Understand the Brain: Neuroimaging by Near-infrared Spectroscopy (Page 9-14) After describing the overview of the recent study of the brain and neurosciences, the development of brain imaging technologies has been mentioned to have contributed extensively to a major branch of neuroscience focused on the correlation of functional brain activity with cognition and behavior. Because the interactive social behavior involving dynamic communications between two individuals is a fundamental aspect of human socialization, the acquisition of real-time NIRS signals of two individuals is a solution for this purpose.
	Posters from ASMS 2017 These articles were selected by Shimadzu. Relating to clinical research, they derive from posters presented at ASMS 2017, held June4-8 in Indianapolis, IN. They feature Shimadzu's state-of-the-art mass spectrometry lineup and include cutting-edge technologies.
	[Bioanalysis] Application of LC-MS/MS Analysis for Time-lapse Metabolomics in CHO Cell Culture (Page 18-22) Metabolic analysis of Chinese hamster ovary (CHO) cell culture plays an important role for efficient production in the biopharmaceutical industry. In this study, amino acids concerned with these pathways were analyzed by LC-MS/MS (LCMS-8050, SHIMADZU) for time-lapse metabolic analysis of CHO-K1 cell batch culture. Results showed real-time changes of various metabolites during CHO culture, which may provide extensive and speedy investigational analysis for genomic and metabolic modifications in biopharmaceutical or medical progresses.
	[Topics] Shimadzu Global Innovation Summit 2017 - IMAGINE, INNOVATE & INSPIRE - (Page 23-24) Shimadzu Corporation held its first Global Innovation Summit in Kyoto, Japan, July 4th & 5th, 2017. The event brought together over 100 scientists from 16 countries in the fields of analytical chemistry and medical diagnostics including 11 Key Opinion Leaders (KOL) who spoke about their application of Shimadzu products to research pressing issues in the areas of human health, food safety and environmental conservation.
	[Topics] Collaboration Between Shimadzu, The Systems Biology Institute, and Osaka University Starting the Provision of an Open Platform Multi-omics Data Analysis Pack (Page 25) On June 6, Shimadzu Corporation starts to provide, at no cost, the Shimadzu Multi-omics Data Analysis Pack. Intended for metabolic engineering, this gadget pack automatically visualizes large-volume of data sets from proteomics, metabolomics, and flux analysis, obtained using Shimadzu gas chromatograph mass spectrometers and liquid chromatograph mass spectrometers, on metabolic maps and perform a variety of data analyses. Multi-omics is a cutting-edge research area in the field of life sciences. It involves the integrated analysis of changes in genes, proteins, metabolites and other substances, towards a holistic elucidation of biological activities at cellular level. Multi-omics is expected to be useful in a variety of fields such as drug discovery, diagnostics, and biofuel research.
	[Topics] Shimadzu Corporation and Phytronix Technologies sign an agreement to offer the first Triple Ion Source (LDTD-MS/MS, ESI-MS/MS and APCI-MS/MS). (Page 26) Kyoto, Japan and Québec, Canada – June 5, 2017. Shimadzu, one of the world's fastest growing mass spectrometry companies, and Phytronix, world leader in high throughput analysis in mass spectrometry, announced that they had signed an agreement to offer the industry’s first Triple Ion Source. Ideal for both screening and confirmation work, this new high-speed platform will significantly improve productivity in high-throughput laboratories performing toxicology, drug discovery and food safety applications. This Triple Ion Source incorporates the Phytronix LDTD (Laser Diode Thermal Desorption Ion Source), and is designed in perfect synchronization with the speed of the Shimadzu LCMS-8060 triple quadrupole mass spectrometer. Together, the companies presented information about this new design at ASMS in Indianapolis.
	[New Products] Nexis GC-2030 (High-End Gas Chromatograph), SPM-8100FM (High Resolution Scanning Probe Microscope), LC/MS/MS Method Package for D/L Amino Acids, Semi-Micro Analytical Balances AP-W Series (Advanced Performance UniBloc Balances) (Page 27)