Nexera lite inert - Características

Aggregates of antibody drugs show immunogenicity and cause a decrease in purification efficiency and production. Therefore, an aggregation test is one of the most critical evaluations when manufacturing biopharmaceuticals and controlling their quality. However, a metal-free LC system is required for good repeatability over a long time due to high-concentration, salt-containing mobile phases such as Sodium chloride. With no metal material in the flow path, Nexera lite inert provides stable aggregate assay results with good repeatability.

Thanks to the outstanding flow-rate stability, the Nexera lite inert provides excellent retention time repeatability.

Analysis of the aggregates in the antibody drug (n=5)

 

In ion exchange or size exclusion chromatography, the pH of the mobile phase sometimes affects the separation of compounds. The pH Monitor, pHM-40, continuously monitors and records the pH of the mobile phase. The pH and detector chromatograms are saved within the same data file and can be overlapped, ensuring efficient data traceability.