LCMS-2020 - Opciones

Dual Ion Source
From HPLC to LCMS, with the LCMS-2020

LCMS-2020 + DUIS-2020

The DUIS-2020 is an optional dual ion source for the LCMS-2020. The dual ion source continuously performs two types of ionization, ESI and APCI, which allows simultaneous analysis of samples suited to either ionization technique.
This increases laboratory efficiency by making it possible to analyze a wide range of chemical species. DUIS ionization is particularly useful in the confirmation of synthetic compounds, or for confirming reaction byproducts and other unknown substances. Pharmaceutical drug discovery groups or any laboratory analyzing both polar and non-polar analytes will benefit from the Dual Ion Source.
(LCMSsolution Version 5 or later)

Operating Principle and Structure of the Dual Ion Source

The Dual ion source simultaneously ionizes samples using two ionization methods - electrospray ionization (ESI), which is suitable for high polarity compounds, and atmospheric pressure chemical ionization (APCI), which is suitable for low-to-medium polarity compounds. Therefore, it is capable of ionizing a wide range of compounds, including chemical classes from low to high polarity.

Enables ESI, APCI, Positive, and Negative Ionization in the Same Analysis

Significantly Improves Efficiency by Simultaneously Analyzing a Wide Variety of Compounds in a Single Run
The following is an example of analysis using the dual ion source. Good response can be obtained for riboflavin by detecting the protonated molecule using ESI, though APCI response is minimal. A good response can also be obtained by ESI for thiamin, but it cannot be detected using APCI. In contrast, for calciferol, the protonated molecule can be detected using APCI, but ionization by ESI is inadequate. All three species are detected with good sensitivity when the DUIS-2020 is employed. In addition to clear advantages in ionization capabilities, the DUIS-2020 yields high quality spectra as shown below.

This ion source is ideal for confirming the molecular weights of synthetic compounds or for simultaneously analyzing a wide range of compounds with polarity ranging from low to high. It also offers higher sensitivity (based on a 2006 study) than other commercially available systems in its class. For some samples, however, sensitivity is lower than using the standard ESI or APCI ion source on the LCMS-2020. Therefore, for the highest sensitivity analysis, the standard ion source may be the best choice.